研究内容の紹介
A Cis-acting Five-amino Acid Motif Controls Targeting of ABCC2 to the Apical Plasma Membrane Domain
*Y. Emi, Y. Yasuda, and M. Sakaguchi
J. Cell Sci. 125, 3133-3143 (2012)
ATP-binding Cassette Transporter Isoform C2 (ABCC2) Localizes to the Apical Plasma Membrane via Interactions with PDZK1 Scaffolding Protein.
*Y. Emi, S. Nomuras, H. Yokota, and M. Sakaguchi
J. Biochem.149, 177-189 (2011)
Multiple Organelle-targeting Signals in the N-terminal Portion of Peroxisomal Membrane Protein PMP70/ABCD3.
S. Iwashita, M. Tsuchida, M. Tsukuda, Y. Yamashita, Y. Emi, Y. Kida, M. Komori, Y. Kashiwayama, T. Imanaka, and *M. Sakaguchi
J. Biochem.147, 581-590 (2010)
Ontogenic Isoform Switching of UDP-glucuronosyltransferase Family 1 in Rat Liver
M. Kishi, *Y. Emi, M. Sakaguchi, S. Ikushiro, and T. Iyanagi
Biochem. Biophys. Res. Commun. 377, 815-819 (2008)
Human ABC Transporter Isoform B6 (ABCB6) Localizes Primarily in the Golgi Apparatus
M. Tsuchida, *Y. Emi, Y. Kida, and M. Sakaguchi
Biochem. Biophys. Res. Commun. 369, 369-375 (2008)
Hepatic UDP-Glucuronosyltransferases Responsible for Glucuronidation of
Thyroxine T4 in Humans
*Y. Kato, S. Ikushiro, Y. Emi, S. Tamaki, H. Suzuki, T. Sakaki, S. Yamada, and M. Degawa
Drug Metab. Dispos. 36, 51-55 (2008)
Thyroxine-metabolizing Rat Uridine Diphosphate-glucuronosyltransferase 1A7 Is Regulated by Thyroid Hormone Receptor
*Y. Emi, S. Ikushiro, and Y. Kato
Endocrinology 148, 6124-6133 (2007)
Peroxisome Proliferator-Activated Receptor Subtypes Differentially Cooperate with Other Transcription Factors in Selective Transactivation of the Perilipin/PEX11a Gene Pair
M. Shimizu, M. H. Akter, Y. Emi, R. Sato, T. Yamaguchi, F. Hirose, and *T. Osumi
J. Biochem. 139, 563-573 (2006)
Monospecific Antipeptide Antibodies Against Human Hepatic UDP- glucuronosyltransferase 1A Family (UGT1A) Isozymes
*S. Ikushiro, Y. Emi, Y. Kato, S. Yamada, M. Degawa, and T. Sakaki
Drug Metab. Pharmacokinet. 21, 70-74 (2006)
Transcriptional Enhancement of UDP-glucuronosyltransferase Form 1A2 (UGT1A2) by Nuclear Factor I-A (NFI-A) in Rat Hepatocytes
*Y. Emi, K. Ueda, A. Ohnishi, S. Ikushiro, and T. Iyanagi
J. Biochem. 138, 313-325 (2005)
Functional Co-expression of Xenobiotic Metabolizing Enzymes, Rat Cytochrome P450 1A1 and UDP-glucuronosyltransferase 1A6, in Yeast Microsomes
S. Ikushiro, M. Sahara, Y. Emi , Y. Yabusaki, and *T. Iyanagi
Biochim Biophys Acta. 1672, 86-92 (2004)
Rapid Proteasomal Degradation of Translocation-deficient UDP-glucuronosyltransferase 1A1 Proteins in Patients with Crigler-Najjar Type II
A. Ohnishi and *Y. Emi
Biochem. Biophys. Res. Commun. 310, 735-741 (2003)
Effect of Spironolactone on the Expression of Rat Hepatic UDP-glucuronosyltransferase
V. A. Catania, M. G. Luquita, E. J. Sanchez, J. M. Pellegrino, S. Ikushiro, Y. Emi, T. Iyanagi, and *A. D. Mottino
Biochem. Pharmacol. 66, 171-177 (2003
Accelerated Degradation of Mislocalized UDP-glucuronosyltransferase Family 1 (UGT1) Proteins in Gunn Rat Hepatocytes
*Y. Emi, S. Omura, S. Ikushiro, and T. Iyanagi
Arch. Biochem. Biophys. 405, 163-169 (2002)
Activation of Glucuronidation through Reduction of a Disulfide Bond in Rat UDP-glucuronosyltransferase 1A6.
S. Ikushiro, Y. Emi, and *T. Iyanagi
Biochemistry 41, 12813-12820 (2002)
Molecular Basis of Perinatal Changes in UDP-glucuronosyltransferase Activity in Maternal Rat Liver.
M. G. Luquita, V. A. Catania, E. J. Pozzi, L. M. Veggi, T. Hoffman, J. M. Pellegrino, S. Ikushiro, Y. Emi, T. Iyanagi, M. Vore, *A. D. Mottino
J. Pharmacol. Exp. Ther. 298, 49-56 (2001)
A 66-Base Pair Enhancer Module Activates the Expression of a Distinct Isoform of UDP-glucuronosyltransferase Family 1 (UGT1A2) in Primary Hepatocytes.
*Y. Emi, A. Ohnishi, T. Kajimoto, S. Ikushiro, and T. Iyanagi
Arch. Biochem. Biophys. 378, 384-392 (2000)
Chemical Modification of Rat Hepatic Microsomes with N-ethylmaleimide Results in Inactivation of both UDP-N-acetylglucosamine-dependent Stimulation of Glucuronidation and UDP-glucuronic Acid Uptake.
S. Ikushiro, Y. Emi, S. Kimura, and *T. Iyanagi
Biochim. Biophys. Acta 1428, 388-396 (1999)
Systematic Mutations of Highly Conserved His49 and Carboxy-terminal of Recombinant Porcine Liver NADPH-cytochrome b5 Reductase Solubilized Domain
S. Kimura, Y. Emi, S. Ikushiro, and *T. Iyanagi
Biochim. Biophys. Acta 1430, 290-301 (1999)
Biochemical and Molecular Aspects of Genetic Disorders of Bilirubin Metabolism
*T. Iyanagi, Y. Emi, and S. Ikushiro
Biochim. Biophys. Acta 1407, 173-184 (1998)
Gene Organization and Genetic Defects of Bilirubin UDP-Glucuronosyltransferase
Y. Emi, S. Ikushiro, and *T. Iyanagi
"Oxygen Homeostasis and Its Dynamics" eds. Y. Ishimura, H. Shimada, and M. Suematsu (Springer, Heidelberg), pp. 248-251 (1998)
Protein-Protein Interactions between UDP-Glucuronosyltransferase Isozymes in Rat Hepatic Microsomes
S. Ikushiro, Y. Emi, and *T. Iyanagi
Biochemistry 36, 7154-7161 (1997)
Xenobiotic Responsive Element-mediated Transcriptional Activation in the UDP-Glucuronosyltransferase Family 1 Gene Complex
Y. Emi, S. Ikushiro, and *T. Iyanagi
J. Biol. Chem. 271, 3952-3958 (1996)
（第68回日本生化学会大会のTOPICS 100に選出されました）
Identification and Analysis of Drug-Responsive Expression of UDP-Glucuronosyltransferase Family 1 (UGT1) Isozyme in Rat Hepatic Microsomes Using Anti-peptide Antibodies
S. Ikushiro, Y. Emi, and *T. Iyanagi
Arch. Biochem. Biophys. 324, 267-272 (1995)
cDNA Cloning of a Putative G Protein-Coupled Receptor from Brain
S. Hata, Y. Emi, T. Iyanagi, and *T. Osumi
Biochim. Biophys. Acta 1261, 121-125 (1995)
Drug-Responsive and Tissue-Specific Alternative Expression of Multiple First Exons in Rat UDP-Glucuronosyltransferase Family 1 (UGT1) Gene Complex
Y. Emi, S. Ikushiro, and *T. Iyanagi
J. Biochem. 117, 392-399 (1995)
A Differnt Cytochrome P-450 Form Is Induced in Primary Cultures of Rat Hepatocytes
Y. Emi, C. Chijiiwa, and *T. Omura
Proc. Natl. Acad. Sci. USA 87, 9746-9750 (1990)
（この論文で学位を授与されました）
Presence of Sex Difference of Cytochrome P-450 in the Rat Preoptic Area and Hypothalamus with Refernce to Coexistence with Oxytocin
K. Hagihara, S. Shiosaka, Y. Lee, J. Kato, O. Hatano, A. Takakusu, Y. Emi, T. Omura, and *M. Tohyama
Brain Res. 515, 69-78 (1990)
Synthesis of Sex-Specific Forms of Cytochrome P-450 in Rat Liver Is Transiently Suppressed by Hepatic Monooxygenase Inducers
Y. Emi and *T. Omura
J. Biochem. 104, 40-43 (1988)
（業界デビューを実質的に果たした論文です）
Purification and Characterization of Three Male-Specific and One Female-Specific Forms of Cytochrome P-450 from Rat Liver Microsomes
T. Matsumoto, Y. Emi, S. Kawabata, and *T. Omura
J. Biochem. 100, 1359-1371 (1986)
（初めての論文：Thanks to Prof. Omura）
